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iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.

Vax1 suppresses dopaminergic neuron phenotype by inhibiting Pax6 expression in the subventricular zone of the lateral ventricle and is necessary to generate Calbindin interneurons for the postnatal olfactory bulb.

A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.

Novel binding sites within a chordotonal-specific enhancer of the delilah gene integrates opposing signals of Prospero and D-Pax2 to control the alternative differentiation programs of cap versus scolopale cells.

The vertebrate neural plate border is comprised of precursors that coexpress multiple lineage markers and small changes in their levels can bias border cell fate.

In fusion-positive rhabdomyosarcoma, CHD4 positively regulates super-enhancer-mediated gene expression by allowing a chromatin architecture at these cis-regulatory regions, which is permissive to the binding of the transcription factor PAX3-FOXO1.

A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.

Chromatin remodeler Hmga1 has two separable functions in neural crest development, first neural crest specification at the neural plate border and later in Wnt-dependent emigration from the neural tube.

The functional relevance of stem cell niche perturbation in sarcomagenesis is defined and the mouse model presented provides a rationale for the use of combination therapy for the treatment of genetically heterogeneous sarcomas.

Organoids are useful in studying guidance cues for retinal ganglion cell (RGC) axon generation and regeneration, and the method of RGC isolation via CNTN2 facilitates investigating RGC-related retinal diseases such as glaucoma.