The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.
In metastatic NSCLC patients, CHIP showed minimal impact on immunotherapy response but was more prevalent and associated with inflammatory pathways in myeloid cells, particularly in lung squamous cell carcinoma.
Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.
Multiple -omics approaches have provided valuable insight into the pathobiology of pediatric acute respiratory distress syndrome, and novel unbiased techniques hold promise for future discoveries.
