559 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

    Kotdaji Ha et al.
    Soluble fragments cleaved from the N-terminus of PC-1 activate the PC-1/PC-2 heteromeric polycystin channel, describing for the first time that the N-terminus itself is an endogenous ligand.
    1. Neuroscience

    Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

    Sahana Sitaraman et al.
    A protein that is a building block of intercellular bridges between neurons promotes their ability to grow dendrites and make synapses.
    1. Neuroscience

    Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex

    Wuqiang Guan et al.
    Our work demonstrated that eye opening differentially modulates inhibitory synaptic transmission from Sst-INs and FS-INs to excitatory neurons in the mammalian cortex.
    1. Neuroscience

    Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

    Attila Ozsvár et al.
    Summation of metabotropic GABAergic responses remain linear even if most superficial layer interneurons specialized to recruit GABAB receptors are simultaneously active.
    1. Structural Biology and Molecular Biophysics

    Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

    Zhening Zhang et al.
    Integrative structural analyses of human insulin degradingenzyme (IDE) reveal how IDE selectively degrades peptides that form toxicaggregates, which guides IDE-based therapeutic innovations to treat diabetesand Alzheimer's disease.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states

    Sumin Jang et al.
    Mammalian germ layer differentiation is characterized by transitions through discrete cell states, which are transcriptionally as well as functionally distinct.
    1. Neuroscience

    A neural-level model of spatial memory and imagery

    Andrej Bicanski, Neil Burgess
    The BB model explains spatial cognition in terms of interactions between specific neuronal populations, providing a common computational framework for the human neuropsychological and in vivo animal electrophysiological literatures.
    1. Microbiology and Infectious Disease

    A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

    Noopur Dave et al.
    Structurally divergent bacterial-like mechanosensitive channels control multiple cellular functions in protozoan parasites.
    1. Cell Biology

    Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

    Ryan S D'Souza et al.
    Calcium influx stimulates formation of ER/plasma membrane contacts adjacent to focal adhesions, and lipid transfer at these sites is required for adhesion disassembly during cell migration.
    1. Neuroscience

    Mapping brain-behavior space relationships along the psychosis spectrum

    Jie Lisa Ji et al.
    A data-reduced neuro-behavioral geometry in psychosis spectrum disorders mapped symptoms stably on to distinct functional brain regions and offers a framework for informing personalized treatment selection decisions.

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