563 results found
    1. Neuroscience

    Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females

    Minsik Yun, Do-Hyoung Kim ... Young-Joon Kim
    Identification of central neural circuits and sensory pathways underlying social-sexual modulation of sperm ejection in female Drosophila unraveled cryptic mate choice, a mechanism of post-copulatory sexual selection.
    1. Neuroscience

    The neural basis for a persistent internal state in Drosophila females

    David Deutsch, Diego Pacheco ... Mala Murthy
    A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
    1. Neuroscience

    Cell types and neuronal circuitry underlying female aggression in Drosophila

    Catherine E Schretter, Yoshinori Aso ... Gerald M Rubin
    A discrete group of interconnected neurons are shown to drive aggressive social interactions in Drosophila females and genetic tools to manipulate these neuronal cell types are provided.
    1. Genetics and Genomics
    2. Physics of Living Systems

    Coarsening dynamics can explain meiotic crossover patterning in both the presence and absence of the synaptonemal complex

    John A Fozard, Chris Morgan, Martin Howard
    Mathematical modelling, together with super-resolution imaging in Arabidopsis, demonstrates that a recently proposed coarsening model for meiotic crossover interference can explain the dynamic patterning of crossovers in many contexts, including in zyp1 and pch2 chromosome structure mutants.
    1. Neuroscience

    Mating activates neuroendocrine pathways signaling hunger in Drosophila females

    Meghan Laturney, Gabriella R Sterne, Kristin Scott
    Postmated increases in sucrose consumption in Drosophila melanogaster females is executed by a female specific circuit that alters neuroendocrine centers to promote hunger.
    1. Neuroscience

    The function of juvenile–adult transition axis in female sexual receptivity of Drosophila melanogaster

    Jing Li, Chao Ning ... Chuan Zhou
    Prothoracicotropic hormone and ecdysone belonging to the insect PG axis modulate virgin female sexual receptivity.
    1. Genetics and Genomics

    Genomic regions controlling shape variation in the first upper molar of the house mouse

    Luisa F Pallares, Ronan Ledevin ... Sabrina Renaud
    An association mapping in wild mice revealed the first candidate loci for within-population molar shape variation and the phenotypic impact of such candidate loci was quantified and validated.
    1. Structural Biology and Molecular Biophysics

    Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

    Shristi Pawnikar, Brenda S Magenheimer ... Yinglong Miao
    Structural dynamic insights revealed the mechanisms of PC1 activation by stalk-derived peptide agonists which can form a foundation for development of PC1 as a therapeutic target for ADPKD treatment.
    1. Structural Biology and Molecular Biophysics

    State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

    Yein Christina Park, Bharat Reddy ... José D Faraldo-Gómez
    A theory is presented that explains why some ion channels tend to open in response to membrane stretching, which posits that channel closing is disfavored by the morphological energetics of the lipid bilayer, and increasingly so under lateral tension.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics

    Jeremiah Keyes, Ambhighainath Ganesan ... Jin Zhang
    An individual extracellular signal regulates multiple cellular actions through differences in the temporal dynamics of spatially distinct populations of the central signaling enzyme, extracellular-signal regulated kinase.

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