7,584 results found
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

    Toshiyuki Oda, Haruaki Yanagisawa ... Tatsuyoshi Kawamura
    A honeycomb-lattice assembly within the skin and mucosa protects us from invading pathogens.
    1. Structural Biology and Molecular Biophysics

    Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

    Kazumasa Oda, Takashi Nomura ... Osamu Nureki
    Time-resolved serial femtosecond crystallography revealed retinal kink and early changes in channelrhodopsin, which leads to the ion pore formation.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa, Cody J Hall ... Matthew A Perugini
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Neuroscience

    Offline replay supports planning in human reinforcement learning

    Ida Momennejad, A Ross Otto ... Kenneth A Norman
    fMRI evidence for off-task replay predicts subsequent replanning behavior in humans, suggesting that learning from simulated experience during replay helps update past policies in reinforcement learning.
    1. Microbiology and Infectious Disease

    Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

    Pia Ryt-Hansen, Jesper Schak Krog ... Lars Erik Larsen
    The abundance and complex genetic diversity of swIAV were documented and the zoonotic potential evaluated.
    1. Genetics and Genomics

    High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models

    Thomas J O'Brien, Ida L Barlow ... André EX Brown
    High-throughput animal tracking and quantitative behaviour analysis detects diverse phenotypes in genetic disease models at a scale that makes drug screens possible.
    1. Neuroscience

    Resource-rational account of sequential effects in human prediction

    Arthur Prat-Carrabin, Florent Meyniel, Rava Azeredo da Silveira
    A proposed model of optimal inference under cognitive costs accounts for human sequential effects, including subtle patterns of attractive and repulsive influence of past observations, in a binary prediction task across a wide range of stimulus conditions.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction

    Fabio Da Silva, Fariba Jian Motamedi ... Andreas Schedl
    Lineage tracing and genetic experiments resolve a long-standing controversy by showing that retinoic acid signaling is active in cardiomyocytes, both during development and after myocardial infarction, and protects damaged hearts from apoptosis.
    1. Cell Biology
    2. Neuroscience

    A scalable and modular automated pipeline for stitching of large electron microscopy datasets

    Gayathri Mahalingam, Russel Torres ... Nuno Macarico da Costa
    A novel image processing infrastructure that is capable of processing petascale datasets and can operate on both electron and light microscopy data.
    1. Neuroscience

    Time-resolved parameterization of aperiodic and periodic brain activity

    Luc Edward Wilson, Jason da Silva Castanheira, Sylvain Baillet
    The new method and reported findings address a growing interest in neuroscience for research tools that can reliably decompose brain activity at the mesoscopic scale into interpretable components.

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