Yvette E Fisher, Helen H Yang ... Thomas R Clandinin
FlpStop is a generalizable tool for conditional gene disruption and rescue and enables critical experiments examining the interactions between genes, circuits, and computation.
Daria N Shalaeva, Dmitry A Cherepanov ... Armen Y Mulkidjanian
In potassium-dependent NTPases, insertion of the activating potassium ion into the active site leads to rotation of the gamma-phosphate yielding a near-eclipsed, catalytically productive conformation of the triphosphate chain.
Patrícia A Correia, Eran Lottem ... Zachary F Mainen
Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
Olivier Cochet-Escartin, Mete Demircigil ... Jean-Paul Rieu
Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
Jennifer A Taylor, Benjamin P Bratton ... Nina R Salama
The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
Isw1 acts as a master regulator in modulating the expression of drug-resistance genes, and this regulatory mechanism is dependent on the interaction of Isw1 acetylation and ubiquitination.
A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
Colleen M Palmateer, Catherina Artikis ... Michelle N Arbeitman
A single-cell RNA-seq study examining gene expression profiles in neurons that underlie Drosophila reproductive behaviors shows males and females build sex-specific behaviors at the molecular-genetic level by overlaying sex-specific information on core gene expression networks.
