10,165 results found
    1. Immunology and Inflammation

    TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

    Marije Baas et al.
    The interplay between the cytokine TGFβ and the PD-1/PD-L1 pathway promotes CD8+ T cell anergy and tolerance towards transplanted tissues.
    1. Immunology and Inflammation

    Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

    Rhoanne C McPherson et al.
    Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.
    1. Neuroscience

    PDF neuron firing phase-shifts key circadian activity neurons in Drosophila

    Fang Guo et al.
    A few circadian ‘evening’ neurons within the Drosophila brain play a key role in driving activity as well as keeping time, whereas the well-known PDF-containing morning cells are likely involved in integrating and transmitting light information.
    1. Immunology and Inflammation

    Tumor control via targeting PD-L1 with chimeric antigen receptor modified NK cells

    Yvette Robbins et al.
    Human NK cells engineered to express a PD-L1 chimeric antigen receptor can control murine and human tumors and reduce myeloid cells expressing high levels of PD-L1.
    1. Neuroscience

    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

    Liang Zhou et al.
    Gab1 is a key downstream effector of PDGF signaling and essential to oligodendrocyte differentiation by linking PDGF signaling with GSK3β/β-catenin module.
    1. Genetics and Genomics

    Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

    Arpan C Ghosh et al.
    A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.
    1. Cell Biology
    2. Developmental Biology

    The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

    Ying-Ju Chang et al.
    PDZ-RhoGEF controls adipose tissue abundance and whole body metabolism.
    1. Developmental Biology

    Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly

    Joshua Bloomekatz et al.
    Studies in zebrafish and mouse implicate the PDGF signaling pathway in the communication between the endoderm and the myocardium that drives medial myocardial movement and thereby initiates cardiac morphogenesis.
    1. Computational and Systems Biology
    2. Developmental Biology

    Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways

    Harish N Vasudevan et al.
    PDGF and FGF signal via distinct intracellular pathways to confer different cellular outcomes during craniofacial development.
    1. Structural Biology and Molecular Biophysics

    An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors

    Fei Ye et al.
    Biochemical and structural studies uncover an unexpected mode of interaction, with unprecedented high affinity, between INAD scaffold and NORPA that is critical for Drosophila compound eye photo-transduction.

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