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Page 2 of 1,156
Epidemiology and Global Health
Spatio-temporal associations between deforestation and malaria incidence in Lao PDR
Francois Rerolle et al.
Deforestation near villages is associated with short-term increases but long-term decreases in malaria incidence in Lao PDR, highlighting the influence of forest-going populations on malaria transmission in the region.
Chromosomes and Gene Expression
Immunology and Inflammation
Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
Kevin W Ng et al.
An ancient integration of an endogenous retroelement in the gene encoding PD-L1 is exapted to generate a soluble form that antagonises the suppressive function of the membrane-bound form.
Immunology and Inflammation
Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy
Alok Kumar et al.
Downregulation of mitochondrial activity by immunosuppressive tumor-derived soluble factors leads to systemic unresponsiveness to the PD-1 blockade therapy.
Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations
Andrew M Garrett et al.
Mammalian Dscams require different intracellular interactions in different cell types during neural circuit formation to promote self-avoidance.
GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab
Daiki Kato et al.
The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.
PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of
Zoë A Hilbert, Dennis H Kim
Sex-specific neuropeptide signaling in the shared sensory nervous system regulates sexually dimorphic gene expression and male-specific behavior in
The role of PDF neurons in setting the preferred temperature before dawn in
Xin Tang et al.
, key neurons controlling sleep play an important role in adjusting the temperature set-point before dawn via time-dependent neuronal plasticity within the clock circuits.
Physics of Living Systems
Computational and Systems Biology
Probing protein flexibility reveals a mechanism for selective promiscuity
Nicolas A Pabon, Carlos J Camacho
Conserved contacts on cognate ligands trigger an induced fit pathway that confers selective promiscuity to PD-1, a flexible regulatory protein and promising anticancer target.
Structural Biology and Molecular Biophysics
Engineering a conserved RNA regulatory protein repurposes its biological function
Vandita D Bhat et al.
Motif length plays a critical role in the specification of biological function within a conserved family of RNA-binding proteins.
Biochemistry and Chemical Biology
A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density
Ward G Walkup IV et al.
The α1 isoform of synGAP restricts the binding of AMPA-receptors and other regulatory proteins to PSD-95, and thus regulates synaptic strength.
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