233 results found
    1. Neuroscience

    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

    Liang Zhou et al.
    Gab1 is a key downstream effector of PDGF signaling and essential to oligodendrocyte differentiation by linking PDGF signaling with GSK3β/β-catenin module.
    1. Developmental Biology

    Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly

    Joshua Bloomekatz et al.
    Studies in zebrafish and mouse implicate the PDGF signaling pathway in the communication between the endoderm and the myocardium that drives medial myocardial movement and thereby initiates cardiac morphogenesis.
    1. Genetics and Genomics

    Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

    Arpan C Ghosh et al.
    A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Pdgfra marks a cellular lineage with distinct contributions to myofibroblasts in lung maturation and injury response

    Rongbo Li et al.
    Lineage tracing using a knockin Pdgfra-rtTA tool indicates distinct contributions of this cell lineage to myofibroblasts in normal development, fibrosis and bronchopulmonary dysplasia models.
    1. Cell Biology
    2. Developmental Biology

    Dynamic control of adipose tissue development and adult tissue homeostasis by platelet-derived growth factor receptor alpha

    Sunhye Shin et al.
    Combined fate mapping and genetic deletion studies reveal that PDGFRα+ cells and PDGFRα gene itself are required for adipose tissue development but not for adult tissue homeostasis.
    1. Cancer Biology

    Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

    Sophia M Blake et al.
    Deletion of the ATM cofactor ATMIN reduces PDGFRA expression and strongly suppresses tumorigenesis in a TP53-deficient mouse model of glioblastoma.
    1. Computational and Systems Biology
    2. Developmental Biology

    Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways

    Harish N Vasudevan et al.
    PDGF and FGF signal via distinct intracellular pathways to confer different cellular outcomes during craniofacial development.
    1. Genetics and Genomics

    Metabolism: Muscle signals to the rescue

    Arely V Diaz, Tânia Reis
    The skeletal muscle of fruit flies communicates with other organs to prevent the accumulation of too much fat and to protect adults against obesity.
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    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

    Yoko Ogawa et al.
    PDGFRα+ Sca-1+ bone marrow stromal/stem cells in whole bone marrow grafts can trigger the onset of autoimmune-related fibrosis in a mouse model of scleroderma.
    1. Stem Cells and Regenerative Medicine

    Haematopoietic Stem Cells: Uncovering the origins of a niche

    Jeff M Bernitz, Kateri A Moore
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