57 results found
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang et al.
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
    1. Cell Biology

    G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion

    Vladimir Purvanov et al.
    siRNA knockdown experiments reveal in detail the signaling pathway that controls cytoskeletal function during cell-in-cell invasion.
    1. Structural Biology and Molecular Biophysics

    Gating mechanisms during actin filament elongation by formins

    Fikret Aydin et al.
    Formins slow elongation of actin filament by either sterically blocking the addition of actin subunits or flattening the helical twist of the filament end.
    1. Cell Biology

    Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

    Keigo Araki et al.
    TNF-α treatment induces phosphorylation and cytoplasmic translocation of the retinoblastoma protein, which regulates cytoskeletal organization in skeletal muscle cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Modulation of formin processivity by profilin and mechanical tension

    Luyan Cao et al.
    Profilin helps to maintain formin at the growing barbed end of an actin filament, while piconewton mechanical tension drastically enhances formin dissociation from the barbed end.
    1. Neuroscience

    Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body

    Michael-John Dolan et al.
    The generation and systematic characterisation of driver lines labelling a large number of neurons in the Drosophila innate olfactory processing centre bridges electron microscopy neuronal reconstructions, circuits and behaviour.
    1. Cell Biology

    A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

    Philippe Bun et al.
    On entry to meiosis, chromosomes scattered in the large oocyte nucleus of starfish are collected by an F-actin network, which contracts by an unexpected, myosin-independent mechanism based on local assembly and global disassembly of actin filaments.
    1. Cancer Biology
    2. Genetics and Genomics

    Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

    Shixiang Wang et al.
    Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.
    1. Cell Biology

    Generation of stress fibers through myosin-driven reorganization of the actin cortex

    Jaakko I Lehtimäki et al.
    Live-cell microscopy studies revealed that stress fibers can be generated de novo from the actin cortex without the involvement of stress fiber precursors.
    1. Biochemistry and Chemical Biology

    Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

    Ryan Paxman et al.
    The small molecule, 147, is a pro-drug that preferentially activates ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins involved in regulating ATF6 activity.

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