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    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    Mitochondrial genomes of Pleistocene megafauna retrieved from recent sediment layers of two Siberian lakes

    Peter Andreas Seeber, Laura Batke ... Laura S Epp
    Abundant mitochondrial DNA of long-extinct large mammals in recent sediment of Siberian lakes suggests complex taphonomic redistribution.
    1. Neuroscience

    Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

    Lorenz Deserno, Rani Moran ... Raymond J Dolan
    Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli

    Avi I Flamholz, Eli Dugan ... David F Savage
    A bacterial CO2 concentrating mechanism enables Escherichia coli to fix CO2 from ambient air into biomass.
    1. Computational and Systems Biology
    2. Medicine

    Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

    Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez
    Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

    Anna Plana-Bonamaisó, Santiago López-Begines ... Ana Méndez
    The nucleotide sensing ability of IMPDH1 at the Bateman domain is regulated by light-dependent phosphorylation in the retina, to adjust GTP synthesis to illumination conditions.
    1. Neuroscience

    Humans use forward thinking to exploit social controllability

    Soojung Na, Dongil Chung ... Xiaosi Gu
    People use vmPFC-dependent forward thinking to guide social choices and exploit the controllability of social environments, expanding the role of this neurocomputational mechanism beyond spatial and cognitive mapping.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease

    Ryan C Vignogna, Mariateresa Allocca ... Gregory I Lang
    Experimental evolution of yeast models of congenital disorders of glycosylation reveals that reduction, but not loss, of phosphoglucomutase activity best compensates for impaired phosphomannomutase activity.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

    Max Renner, Mattia Bertinelli ... Jonathan M Grimes
    A structural comparison of different states of the protein responsible for encapsidation of the viral RNA genome provides mechanistic insights into this process.
    1. Microbiology and Infectious Disease

    Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense

    Kelsey Michelle Wells, Kai He ... Paul de Figueiredo
    Brucella facilitates its intracellular parasitism by hijacking the host-regulated IRE1α-dependent decay (RIDD)-BLOS1 innate immune defense system through the disassembly of the BLOC-1-related complex that results in the perinuclear trafficking of Brucella-containing vacuoles and enhanced susceptibility to infection.