Browse the search results

Page 2 of 6
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    σ28-dependent small RNA regulation of flagella biosynthesis

    Sahar Melamed, Aixia Zhang ... Gisela Storz
    σ28-Dependent sRNAs fine-tune flagella synthesis, with one sRNA connecting synthesis with metabolism and two sRNAs with opposing effects connecting synthesis with ribosomal protein production through unique binding within coding sequences.
    1. Developmental Biology

    Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

    Wilma Tixi, Maricela Maldonado ... Hung Ping Shih
    ECM-Itgb1 signaling and cell-cell adhesion are pivotal and coordinate together to regulate pancreatic islet aggregation, architecture, and functional maturation during development.
    1. Cell Biology

    Cas phosphorylation regulates focal adhesion assembly

    Saurav Kumar, Amanda Stainer ... Jonathan A Cooper
    A novel two-step model for integrin activation primed by Cas during cell migration and spreading on multiple extracellular matrix ligands.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

    Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch
    The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Neuroscience

    Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions

    Irene Navarro Lobato, Adrian Aleman-Zapata ... Lisa Genzel
    Increasing cortical plasticity leads to better one-trial memory but more interference effects on semantic-like memory.
    1. Cell Biology
    2. Neuroscience

    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

    Holly H Black, Jessica L Hanson ... Alexandra M Whiteley
    Exploring how UBQLN2 mutations cause ALS leads to the discovery of a pathway by which an ancient retroelement changes gene expression in human cells.
    1. Microbiology and Infectious Disease
    2. Biochemistry and Chemical Biology

    Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

    Sebastian Strauss, Julia Acker ... Ralf Jungmann
    Spatial transcriptomics analysis of rotavirus replication factories reveals principles of viral transcript partitioning and RNA stoichiometry in these granules.
    1. Neuroscience

    NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

    Brandon W Hughes, Benjamin M Siemsen ... Makoto Taniguchi
    Social defeat stress induces transcription factor Npas4 expression in the medial prefrontal cortex and its chronic stress-induced changes in excitatory synaptic transmission, reduction of dendritic spine density, and anhedonia-like behaviors.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway

    Robert Krause, Jumari Snyman ... Alasdair Leslie
    A skewed B cell response in people living with HIV proceeds via an extrafollicular path and could result in reduced affinity B cell memory and antibody responses.