66 results found
    1. Neuroscience

    Amygdala neural activity reflects spatial attention towards stimuli promising reward or threatening punishment

    Christopher J Peck, C Daniel Salzman
    Primate amygdala neurons provide a coordinated representation of space and motivational significance whereby amygdala responses to visual stimuli predicting either rewards or aversive stimuli could influence spatial attention in a similar manner.
    1. Neuroscience

    SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans

    Xiaoyan Guo, L René García
    A protein called SIR-2.1 helps to protect worms from the effects of aging by regulating metabolic processes that would otherwise generate damaging reactive oxygen species.
    1. Cell Biology
    2. Immunology and Inflammation

    Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity

    Scott B Thompson et al.
    Lymphocyte migration and autoimmunity induction rely on Formin-like 1-mediated actin network remodeling to push the lymphocyte nucleus through restrictive endothelial barriers.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

    Ruihua Ma et al.
    Mouse genetic approaches show that multiple Wnt endothelial sources orchestrate the spatiotemporal distribution of hepatocyte functions during liver maturation and respecify metabolic zonation during liver repair.
    1. Neuroscience

    In vivo assessment of the neural substrate linked with vocal imitation accuracy

    Julie Hamaide et al.
    Song learning accuracy can be predicted and traced in the structural properties of the brains of juvenile male zebra finches already at 20 days post-hatching.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Gene activation by a CRISPR-assisted trans enhancer

    Xinhui Xu et al.
    Both exogenous and endogenous genes can be highly activated in cells by a new dCas9-based activator, CRISPR-assisted trans enhancer, that can be used to activate genes for biomedical applications.
    1. Neuroscience

    Value-based attentional capture affects multi-alternative decision making

    Sebastian Gluth et al.
    Speeded value-based decisions between two options can be affected by a third, high-value distractor that captures attention and slows down the choice process.
    1. Cell Biology

    Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

    Ana Paula Arruda et al.
    Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.
    1. Immunology and Inflammation

    CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

    Yosuke Kumamoto et al.
    CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.

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