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    1. Chromosomes and Gene Expression

    Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster

    Subhendu Roy Choudhury et al.
    Deposition of the exon junction complex is thought to be the missing link between pre-mRNA splicing and translation in multicellular organisms, but no evidence of such deposition has been found in Drosophila.
  1. Meta-Research: Journal policies and editors’ opinions on peer review

    Daniel G Hamilton et al.
    A survey of journals and editors in five areas of research - ecology, economics, medicine, physics and psychology - reveals a range of differences in their approach to peer review.
  2. Meta-Research: Large-scale language analysis of peer review reports

    Ivan Buljan et al.
    The linguistic characteristics of peer review reports are not influenced by research area, type of review or reviewer gender, which is evidence for the robustness of peer review.
    1. Cell Biology
    2. Genetics and Genomics

    Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse

    Yael Riahi et al.
    mTORC1 inhibition by perinatal ER stress induces beta-cell growth arrest with subsequent development of diabetes.
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
  3. Research: Gender bias in scholarly peer review

    Markus Helmer et al.
    Gender-bias in peer reviewing might persist even when gender-equity is reached because both male and female editors operate with a same-gender preference whose characteristics differ by editor-gender.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity

    Ramon A van der Valk et al.
    The DNA-bridging efficiency of H-NS, a genome organising and transcription regulatory protein, is modulated by changes in environmental conditions of the cell, which drive a structural rearrangement of the protein.
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa et al.
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

    Guangyan Xiong et al.
    Genetic and biochemical analyses reveal that PERK is important for the survival of activated satellite stem cells during regeneration of injured skeletal muscle.
    1. Cancer Biology
    2. Developmental Biology

    Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

    Carla S Verissimo et al.
    Libraries of patient-derived tumor organoids are a reliable and scalable model system that can help identify and optimize targeted therapies in a pre-clinical setting.