40 results found
    1. Cancer Biology

    Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

    J Edward van Veen et al.
    Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
    1. Neuroscience

    Bmal1 function in skeletal muscle regulates sleep

    J Christopher Ehlen et al.
    Expression of transcription factor BMAL1 in skeletal muscle reduces the recovery response to sleep loss and is both necessary and sufficient to regulate total sleep amount.
    1. Developmental Biology

    TAF7L modulates brown adipose tissue formation

    Haiying Zhou et al.
    TAF7L acts as a molecular switch that regulates the development of mesenchymal stem cells.
    1. Cancer Biology

    Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

    Shawn McGuirk et al.
    Breast cancer resistant to either doxorubicin or epirubicin relies on distinct primary metabolic processes, which can be targeted to reduce cancer progression.
    1. Cell Biology
    2. Medicine

    MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice

    Shilpak Bele et al.
    Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.
    1. Cancer Biology
    2. Cell Biology

    Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

    Cong-Hui Yao et al.
    In addition to increasing glycolysis, some proliferating cells exhibiting the Warburg effect also increase oxidative phosphorylation through mitochondrial fusion.
    1. Neuroscience

    The neural basis for a persistent internal state in Drosophila females

    David Deutsch et al.
    A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
    1. Genetics and Genomics
    2. Neuroscience

    An adipokine feedback regulating diurnal food intake rhythms in mice

    Anthony H Tsang et al.
    Adiponectin signaling integrates metabolic state information to regulate circadian clock function in hypothalamic appetite regulating centers, food intake rhythms, and body weight.
    1. Cell Biology

    Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

    King Faisal Yambire et al.
    Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.
    1. Developmental Biology

    Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

    Haruko Nakano et al.
    During cardiogenesis, the major role of glucose is not the catabolic extraction of energy but the anabolic biosynthesis of nucleotides.

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