The coordinated differential modulation of satiety signaling POMC- and hunger signaling AgRP- neurons in the arcuate nucleus of the hypothalamus assigns an important role to noradrenalin to promote feeding.
Parabrachial neurons expressing CGRP relay affective components of ascending pain information via distinct thalamic and amygdalar pathways, which together contribute to complementary aspects of adaptive threat responses.
AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
Formation and cell pole-localization of chemotactic signaling-arrays is a coupled process mediated by ParP, which drives localized array-assembly and regulates the localization-dynamics of its network constituents.
Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.