The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

Combining particle tracking in living cells with statistical analysis demonstrates how the oligomeric organization of cell surface receptor influences their function, a necessary step in the development of drugs targeting specific receptor conformation.

TIR-1 regulates both repair and destruction on either side of an injury axon.

Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.

Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.