1,766 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

    Emma A Morrison et al.
    The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
    1. Human Biology and Medicine

    Point of View: Competency-based assessment for the training of PhD students and early-career scientists

    Michael F Verderame et al.
    A method to assess the training of scientists, based on a set of 10 core competencies, is proposed.
    1. Cell Biology

    A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

    Matthias Christoph Munder et al.
    The cytoplasm behaves as an adaptable fluid that can reversibly transition into a protective solid-like state upon stress.
  1. Research: Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Kenneth D Gibbs Jr et al.
    A systems-level analysis of the biomedical workforce in the US shows that current strategies to enhance faculty diversity are unlikely to have a significant impact, and that there is a need to increase the number of PhDs from underrepresented minority backgrounds who move on to postdoctoral positions.
    1. Microbiology and Infectious Disease

    Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

    Andrew Tze Fui Liew et al.
    Inside the acidic vacuole, expression, DNA binding and DNA binding affinity of the Salmonella regulator SsrB is stimulated by acid pH.
    1. Cell Biology

    A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions

    Stephan A Eisler et al.
    The small GTPase Rho connects GPCR signaling with PKD activity at TGN membranes and consequently anterograde trafficking to focal adhesions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

    Yvonne Vercoulen et al.
    The Ras activator RasGRP1 that impacts Ras signals in immune cells, leukemias, and colorectal cancer, switches to an active conformation aided by a pH-sensitive histidine residue in a central location of the RasGRP1 molecule.
    1. Neuroscience

    Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH

    Jessica A Haley et al.
    The rhythms generated by the stomatogastric and cardiac ganglia of the Jonah crab are surprisingly robust but differentially sensitive to acute changes in extracellular pH from pH 5.5 to 10.4.
    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu et al.
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
  2. Point of View: A fair deal for PhD students and postdocs

    Henry R Bourne
    The relentless expansion that threatens the sustainability of biomedical research in the US takes a heavy toll on young researchers.

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