The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
An analysis of papers in which two or more authors shared first-author position found that male authors were more likely than female authors to appear first in the author list.
The challenges faced by new PIs in the UK include difficulties in recruiting PhD students, maintaining a good work-life balance and securing permanent positions.
The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.
A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.
Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
