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    1. Cell Biology

    CDK1 controls CHMP7-dependent nuclear envelope reformation

    Alberto T Gatta et al.
    CHMP7 is phosphorylated by CDK1 upon mitotic entry, preventing interaction with LEM2 and inappropriate assembly during mitotic exit.
    1. Neuroscience

    Sensory coding and the causal impact of mouse cortex in a visual decision

    Peter Zatka-Haas et al.
    Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Social fluidity mobilizes contagion in human and animal populations

    Ewan Colman et al.
    A new way of measuring sociality in human and animal contact networks reveals the link between social behavior, population density, and disease transmission.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

    Joshua C D'Aeth et al.
    Selection by national-level antibiotic consumption and vaccination trends drives atypical recombinations, frequently resulting in interspecies sequence exchange at many sites across a bacterial species’ chromosome.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

    Liz Hernandez Borrero et al.
    Anti-tumor properties of sub-class of xanthine analogs involve restoration of p53 pathway transcriptome, independent of p53/p73, dependent on ATF3/ATF4 and Noxa in mutated-p53 tumors and the compounds trigger an S-phase checkpoint.
    1. Cell Biology
    2. Neuroscience

    An autoinhibitory clamp of actin assembly constrains and directs synaptic endocytosis

    Steven J Del Signore et al.
    Autoinhibition allows synaptic endocytic actin regulators to pre-deploy to synaptic membranes at high concentrations and constrains actin assembly to productive events.
    1. Neuroscience

    Disrupting cortico-cerebellar communication impairs dexterity

    Jian-Zhong Guo et al.
    The flow of neural activity across the cortico-cerebellar loop enables mice to reach for objects with skill and precision.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

    Shintaro Ide et al.
    Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.
    1. Biochemistry and Chemical Biology

    Structure-guided microbial targeting of antistaphylococcal prodrugs

    Justin J Miller et al.
    Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.