175 results found
    1. Structural Biology and Molecular Biophysics

    Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19

    Cheng Dong et al.
    Complex structures of Tudor domains of PHF1/19 with H3tK27me3 provide structural basis for preferential recognition of H3tK27me3 over canonical H3K27me3, implicating that H3tK27me3 might be a physiological ligand of PHF1/19.
    1. Chromosomes and Gene Expression

    PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells

    Payal Jain et al.
    Depletion of PHF19 in prostate cancer cells leads to an increase in MTF2 and PRC2 chromatin occupancy causing deregulation of key genes critical for proliferation and metastasis.
    1. Structural Biology and Molecular Biophysics

    Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

    Ruobo Zhou et al.
    Analyzing single molecules reveals that Pif1 family helicases periodically patrol DNA, which may explain this enzyme's ability to suppress genome instability at G-quadruplex motifs and transcriptional RNA-DNA hybrids (R-loops).
    1. Cell Biology
    2. Developmental Biology

    miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6

    Eleonora Franzoni et al.
    The regulation of Phf6 by miR-128 is a developmental timing mechanism that influences cortical lamination, neuronal morphology and intrinsic excitability.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3

    Ho-Ryun Chung et al.
    PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.
    1. Chromosomes and Gene Expression

    A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

    Jonathan Strecker et al.
    A sharp transition in the fate of DNA ends with telomere sequences is identified, which suggests a boundary between DNA double-strand breaks and telomeres.
    1. Chromosomes and Gene Expression

    The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes

    Adrien Birot et al.
    Cohesin loader activity is regulated by phosphorylation of its cohesin substrate.
    1. Structural Biology and Molecular Biophysics

    DNA Helicases: Molecular watchdogs on genome patrol

    Gheorghe Chistol, Johannes Walter
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    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

    Aurèle Piazza et al.
    A combination of genetics and biophysical approaches identifies an overlapping set of sequences that form non-canonical G-quadruplex structures in vitro and induce genomic instability in cells.
    1. Chromosomes and Gene Expression

    The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast

    Io Nam Wong et al.
    Genomic deletions formed from inter-fork strand annealing associated with a collapsed replication fork are suppressed by the FANCM-related DNA helicase Fml1 in conjunction with its partner proteins Mhf1 and Mhf2.

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