79 results found
    1. Cell Biology
    2. Developmental Biology

    Apical targeting of the formin Diaphanous in Drosophila tubular epithelia

    Tal Rousso et al.
    Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.
    1. Cell Biology

    Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons

    Pratibha Narayanan et al.
    Local Mtmr2 activity and PI(3,5)P2 abundance dynamically control Piezo2-dependent mechanotransduction in peripheral sensory neurons.
    1. Cell Biology

    A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

    Ramiro Nández et al.
    Studies of Lowe syndrome patient cells, which lack the inositol 5-phosphatase OCRL, suggest that a defect in endocytosis plays a role in the pathological manifestations of the disease.
    1. Cell Biology

    GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

    Marina Besprozvannaya et al.
    Functionally distinct ER-PM domains in human cells are defined by conserved GRAM domain containing proteins.
    1. Cell Biology

    Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution

    Julie Jouette et al.
    In Drosophila oocytes, the exclusion of the scaffold protein PAR3 from the posterior cortex depends on PAR1 and endocytosis, while its anterior localisation requires microtubules and recycling endosomes.
    1. Plant Biology

    Structural basis for plant plasma membrane protein dynamics and organization into functional nanodomains

    Julien Gronnier et al.
    Unprecedented resolution of the molecular mechanisms of plant membrane protein anchoring involving phospholipids and sterols reveals the control of spatio-temporal segregation into plasma membrane nanodomains.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring

    Frauke Mücksch et al.
    PI(4,5)P2 plays a much broader role during the HIV-1 particle assembly process than assumed; it is indispensable not only for recruitment of Gag to the plasma membrane but also for the maintenance of Gag assemblies.
    1. Biochemistry and Chemical Biology

    Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

    Susanne Gerndt et al.
    The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

    Charlotte F Kelley et al.
    In vitro reconstitution of the core focal adhesion proteins talin and vinculin with actin reveals lipid-dependent release of autoinhibition.
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of phospholipid activation of the human TPC2 channel

    Ji She et al.
    Cryo-EM structures of human TPC2 channel in the ligand-bound and apo states reveal the structural mechanism of PI(3,5)P2 lipid regulated gating of TPC2.

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