124 results found
    1. Structural Biology and Molecular Biophysics

    Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

    Ruobo Zhou et al.
    Analyzing single molecules reveals that Pif1 family helicases periodically patrol DNA, which may explain this enzyme's ability to suppress genome instability at G-quadruplex motifs and transcriptional RNA-DNA hybrids (R-loops).
    1. Plant Biology

    Shade-induced nuclear localization of PIF7 is regulated by phosphorylation and 14-3-3 proteins in Arabidopsis

    Xu Huang et al.
    A phosphorylation dependent translocation of PIF7 and involvement of 14-3-3 proteins reveal novel regulation mechanisms in shade signal transduction.
    1. Plant Biology

    BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance

    Bo Zhang et al.
    The abundance of the PIF4 transcription factor, central in light and temperature signaling, is controlled by an E3 ligase encoded by BOP proteins.
    1. Chromosomes and Gene Expression

    A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

    Jonathan Strecker et al.
    A sharp transition in the fate of DNA ends with telomere sequences is identified, which suggests a boundary between DNA double-strand breaks and telomeres.
    1. Plant Biology

    Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl

    Eunkyoo Oh et al.
    Signals from major hormones and the environment are integrated in the Arabidopsis hypocotyl to control gene expression and plant stem elongation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

    Aurèle Piazza et al.
    A combination of genetics and biophysical approaches identifies an overlapping set of sequences that form non-canonical G-quadruplex structures in vitro and induce genomic instability in cells.
    1. Cell Biology
    2. Neuroscience

    Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

    Jose F Moruno-Manchon et al.
    G-quadruplex DNA regulates autophagy in neurons.
    1. Plant Biology

    A cis-carotene derived apocarotenoid regulates etioplast and chloroplast development

    Christopher I Cazzonelli et al.
    Carotenoids are not just required as core components for plastid biogenesis, they can be cleaved into an apocarotenoid signal that regulates etioplast and chloroplast development during extended periods of darkness.
    1. Structural Biology and Molecular Biophysics

    DNA Helicases: Molecular watchdogs on genome patrol

    Gheorghe Chistol, Johannes Walter
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    1. Immunology and Inflammation

    Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

    O Sascha Yousefi et al.
    Controlling the duration of ligand binding to the T cell receptor by light shows that T cells discriminate stimulatory from non-stimulatory ligands by measuring the dynamics of ligand binding.

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