346 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal et al.
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Microbiology and Infectious Disease

    Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

    Jennifer A Taylor et al.
    The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
    1. Neuroscience

    Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network

    Yaara Lefler et al.
    Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
    1. Physics of Living Systems

    High-speed motility originates from cooperatively pushing and pulling flagella bundles in bilophotrichous bacteria

    Klaas Bente et al.
    Bacteria reach swimming speeds of several hundred body lengths per second and change direction in less than 5 ms by using coordinated flagella bundle agitation.
    1. Structural Biology and Molecular Biophysics

    The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

    Ahmad Abdelzaher Zaki Khalifa et al.
    A structure of the ciliary inner junction at 3.6 Å resolution permits atomic modeling of six inner junction proteins and their interactions with acetylated lysine 40 loops of alpha tubulins.
    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim et al.
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Structural Biology and Molecular Biophysics

    Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

    Alison B Hickman et al.
    The tetrameric structure of a casposase bound to DNA and its biochemical properties show how a transposase could have evolved to perform CRISPR-Cas spacer acquisition.
    1. Cell Biology
    2. Neuroscience

    Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

    Chantell S Evans, Erika LF Holzbaur
    In neuronal mitophagy, Parkin and OPTN induce efficient sequestration of damaged somal mitochondria into autophagosomes, but slow turnover via lysosomal acidification may be a point of vulnerability for the cell.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira et al.
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.

Refine your results by:

Type
Research categories