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Evolution of Segmentation: Sox enters the picture
Felix Kaufholz, Natascha Turetzek
The discovery of a gene that regulates two segmentation mechanisms in spider embryos is fueling the ongoing debate about the evolution of this crucial developmental process.
Plant Cytokinesis: Illuminating traffic control for cell–division planes
Human Biology and Medicine
Point of View: Coordinating a new approach to basic research into Parkinson’s disease
Randy Schekman, Ekemini AU Riley
The ASAP initiative will incentivize collaboration between researchers and encourage open-science practices to improve our understanding of the biology underlying Parkinson's disease.
Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA
Míriam Javier-Torrent et al.
EphA signaling plays dual opposite roles on axon dynamics in neurons, so it inhibits and promotes axon growth through ligand binding and receptor processing, respectively.
Coordination of tissue cell polarity by auxin transport and signaling
Carla Verna et al.
controls both auxin transport and auxin signaling to coordinate tissue cell polarity during vein patterning in plants.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
Structure of a bacterial ATP synthase
Hui Guo et al.
Construction of a first atomic model for an intact bacterial ATP synthase allows for a structural understanding of the roles of individual amino acids in the mechanism of ATP synthesis.
Genetics and Genomics
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
Karole N D'Orazio et al.
Cue2 is an endonuclease that cleaves mRNA in the A site of the lagging ribosome upon ribosome collision events.
Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations
Alina Peter et al.
Colored surfaces induce strong gamma-synchronization yet sparse firing in V1 when receptive field inputs are predicted from the surrounding spatial context.
Across-species differences in pitch perception are consistent with differences in cochlear filtering
Kerry MM Walker et al.
Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
A virtual burrow assay for head–fixed mice measures habituation, discrimination, exploration and avoidance without training
Andrew JP Fink et al.
A naturalistic assay for head-fixed mice permits observation of a diverse set of innate and learned behaviors without requiring any training.
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