235 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

    Rosa Della Monica et al.
    The phosphatase Fcp1 inactivates Greatwall kinase at the end of mitosis.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Niels Bradshaw et al.
    Structures of active and inactive conformations of a PP2C family phosphatase reveal a conserved switch that controls enzymatic activity and point to an unexpected relationship between phosphatases and proteasomal proteases.
    1. Cell Biology

    SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

    Sung Jun Bae et al.
    The scaffold protein SAV1 counteracts PP2A to activate Hippo kinases.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

    Xinru Wang et al.
    A novel dynamic charge-charge interaction between B56 and a subset of PP2A-B56 substrates is essential for substrate specificity, dephosphorylation and, for KIF4A, binding condensin I.
    1. Biochemistry and Chemical Biology

    Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity

    Patrick J Nygren et al.
    Flexibility is a defining feature of AKAP kinase-phosphatase assemblies and points toward a mechanism whereby combinatorial recruitment of binding partners tailors the overall conformation of the macromolecular assembly, allowing customized physiological roles.
    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim et al.
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

    Byron C Williams et al.
    The mechanism of inhibition by unfair competition is central to determining the protein phosphorylation states that govern cell cycle transitions between M phase and interphase.
    1. Computational and Systems Biology
    2. Neuroscience

    Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

    Veronica Musante et al.
    A complex interplay between MAST3 and PKA protein kinases and the regulatory protein ARPP-16 allows cAMP to control the activity of protein phosphatase 2A.
    1. Microbiology and Infectious Disease

    Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

    Edward JD Greenwood et al.
    A comprehensive whole cell proteomic map describing expression time courses of >6,500 viral and cellular proteins during HIV infection identifies Vif-dependent antagonism of key cellular phosphatase PP2A.
    1. Cell Biology

    Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

    Giulia Vallardi et al.
    Distinct PP2A-B56 complexes use isoform-selective interactions to localise to either the centromere or kinetochore and control different processes during mitosis.

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