4,118 results found
    1. Neuroscience

    Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia

    Hind Baba Aïssa, Romain W Sala ... Daniela Popa
    In a mouse model of DYT25 dystonia with disruption of striatal neurotransmission by Gnal mutation, the cerebello-thalamic excitability is increased following symptom expression and θ-burst cerebellar stimulations during cholinergic-induced dystonia depress the cerebello-thalamic transmission and reduce the motor symptom severity.
    1. Microbiology and Infectious Disease

    Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

    Pia Ryt-Hansen, Jesper Schak Krog ... Lars Erik Larsen
    The abundance and complex genetic diversity of swIAV were documented and the zoonotic potential evaluated.
    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim, Christian Berrios ... William C Hahn
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Chromosomes and Gene Expression

    Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

    Nicola Manfrini, Michela Clerici ... Maria Pia Longhese
    The conversion of the ends of a double-strand break from double-stranded to single-stranded DNA, which is necessary to initiate homologous recombination, is responsible for loss of transcription and RNA polymerase occupancy around the double-strand break in Saccharomyces cerevisiae.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA

    Matthew T Parker, Katarzyna Knop ... Gordon G Simpson
    The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

    Roman O Fedoryshchak, Magdalena Přechová ... Richard Treisman
    Interaction of cofactor Phactr1 with PP1 creates a composite substrate-binding surface that defines the sequence specificity of the Phactr1/PP1 holoenzyme.
    1. Developmental Biology
    2. Plant Biology

    Cell type boundaries organize plant development

    Monica Pia Caggiano, Xiulian Yu ... Marcus G Heisler
    Leaf position, shape and orientation are pre-patterned by cell type boundaries in the shoot meristem.
    1. Computational and Systems Biology
    2. Neuroscience

    Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

    Veronica Musante, Lu Li ... Angus C Nairn
    A complex interplay between MAST3 and PKA protein kinases and the regulatory protein ARPP-16 allows cAMP to control the activity of protein phosphatase 2A.
    1. Biochemistry and Chemical Biology

    Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms

    Michal Ziemski, Ahmad Jomaa ... Eilika Weber-Ban
    Cdc48-like protein of actinobacteria (Cpa) is a AAA+ proteasomal interactor involved in adaptation of mycobacteria to carbon limitation and potentially influencing ribosomal composition of the cell.
    1. Chromosomes and Gene Expression

    The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay

    Moran Kelbert, Antonio Jordán-Pla ... Mordechai Choder
    Class-specific transcription factor links transcription backtracking with cytoplasmic mRNA decay via co-transcriptional interaction with nascent transcripts.

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