3,909 results found
    1. Developmental Biology

    Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

    Gianpaolo Rando et al.
    Glucocorticoid receptor directly regulates the transcriptional activity of peroxisome proliferator-activated alpha (PPARα) before birth in anticipation of the sudden shifts in the postnatal nutrient source and metabolic demands.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

    Masashi Watanabe et al.
    TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing the PPARγ protein.
    1. Biochemistry and Chemical Biology

    Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway

    Jian Dai et al.
    Curcumin regulates gene expression via PPARa activation and exhibits biological activities involved in amyloidosis, peroxisome proliferation, lipid metabolism, and hepatocyte hypertrophy.
    1. Cancer Biology
    2. Developmental Biology

    Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

    Lorenzo Rinaldi et al.
    Dnmt3a and Dnmt3b are dispensable for epidermal homeostasis but act as potent tumor suppressors regarding skin squamous tumorigenesis.
    1. Cancer Biology

    Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone

    Wing Yin Cheng et al.
    The PPARγ protein acts in macrophages to inhibit breast cancer progression and mediate the anti-tumor effects of rosiglitazone by suppressing Gpr132 – a pro-tumor and pro-inflammatory factor in macrophages.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

    Jinsai Shang et al.
    Synthetic PPARγ ligands push and cobind with natural endogenous ligands, instead of compete and displace, which synergistically affects the structure and function of PPARγ.
    1. Cell Biology

    Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization

    Kalyn Kono et al.
    Par-complex-dependent cell polarity can be cell-autonomously conferred to non-polar Drosophila S2 cells, unveiling temporal patterns toward the cortical localization of Par-complex aggregates that include a meshwork containing unit segments.
    1. Developmental Biology
    2. Evolutionary Biology

    Par protein localization during the early development of Mnemiopsis leidyi suggests different modes of epithelial organization in the metazoa

    Miguel Salinas-Saavedra, Mark Q Martindale
    Even though the ctenophore Mnemiopsis leidyi develops polarized epithelial tissues, polarization is not mediated by the conserved mechanisms polarizing bilaterian and cnidarian epithelial cells.
    1. Stem Cells and Regenerative Medicine

    Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila

    Lisa Zipper et al.
    A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..
    1. Chromosomes and Gene Expression

    Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

    Meredith A Sommars et al.
    B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.

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