713 results found
    1. Cell Biology
    2. Developmental Biology

    Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells

    Elise Houssin et al.
    Baz/Par3 and Sanpdo are required for clustering and activation of Notch receptors to allow intra-lineage private communication following asymmetric division of Drosophila epithelial cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of circular RNAs in primates

    Gabriela Santos-Rodriguez et al.
    An analysis of the genomic features that distinguish conserved from species-specific circular RNAs reveals that the expansion of the downstream intron by insertion of retrotransposons stabilizes circular RNAs' production across 30+ millions years of evolution.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Circular RNA repertoires are associated with evolutionarily young transposable elements

    Franziska Gruhl et al.
    Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.
    1. Neuroscience

    Skipping ahead: A circuit for representing the past, present, and future

    Jennifer C Robinson, Mark P Brandon
    A circuit between the hippocampus, nucleus reunions, and prefrontal cortex organizes information about the past, present, and future into alternating theta sequences.
    1. Cell Biology

    A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

    Sho W Suzuki et al.
    PX-BAR Mvp1 and dynamin-like GTPase Vps1 drive retromer-independent endosomal recycling.
    1. Neuroscience

    Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

    Dennis London et al.
    Subthalamic nucleus spiking activity, beta oscillation power, and locking of spikes to the beta oscillation are decreased prior to changes in ongoing movements.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Common host variation drives malaria parasite fitness in healthy human red cells

    Emily R Ebel et al.
    Human red blood cells from healthy donors display marked biophysical and genetic variation that impacts the growth of Plasmodium falciparum malaria parasites, outside of known disease alleles.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

    Pengyao Jiang et al.
    Certain mutational signatures vary in their contribution to genetic variation across the yeast phylogeny due to genetically encoded natural mutator phenotypes whose activity can be directly measured in the lab.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals

    Michael L Wood et al.
    Human herpesvirus 6B can transition between telomere-integrated and free viral forms, and frequent telomere-loop-driven partial or complete viral genome excision events create mosaicism in germline carriers of inherited chromosomally integrated HHV-6B.
    1. Cell Biology

    Endoplasmic reticulum tubules limit the size of misfolded protein condensates

    Smriti Parashar et al.
    The endoplasmic reticulum (ER) uses ER tubules and specific ER autophagy machinery to prevent toxic, dominant-interfering, disease-causing, mutant proteins from entering the secretory pathway.

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