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    1. Chromosomes and Gene Expression

    RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

    Nathan R Rose et al.
    The E3 ubiquitin ligase activity of polycomb repressive complex 1 is stimulated by RYBP to support a histone modification-dependent communication between polycomb repressive complexes in mice.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

    Roberto Bonasio et al.
    The Polycomb group protein SCML2 contributes to the assembly and gene silencing function of Polycomb Repressive Complex 1 (PRC1) and requires an RNA-binding region to reach chromatin targets.
    1. Chromosomes and Gene Expression

    Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

    Allison W McClure, John FX Diffley
    DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.
    1. Neuroscience

    Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations

    Limei Zhang et al.
    Placing the PACAP/PAC1 signaling within glutamate/GABA cell type and subregional contexts in mouse brain reveals its conspicuous role for sensorimotor circuit interaction through modulating neuronal plasticity.
    1. Biochemistry and Chemical Biology

    Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2

    Yicheng Long et al.
    Biochemical and mutagenesis analysis reveal the long-anticipated RNA-binding elements of Polycomb Repressive Complex 2 (PRC2), an important chromatin modifier, allowing construction of separation-of-function mutants of PRC2 defective in RNA binding but retaining histone-modifying activity.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

    Rosa María Marión et al.
    Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
    1. Structural Biology and Molecular Biophysics

    Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A

    Sithara Wijeratne, Radhika Subramanian
    Geometrical features of microtubule arrays regulate the collective activity of motor and non-motor proteins.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

    Chao Yu Zhen et al.
    Live-cell single-molecule tracking reveals that hierarchical cooperation within the Polycomb Cbx7 protein between the low-affinity H3K27me3-binding module and the high-affinity DNA-binding cassette targets Polycomb repressive complex 1 to chromatin.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri et al.
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Cell Biology

    Two subunits of human ORC are dispensable for DNA replication and proliferation

    Etsuko Shibata et al.
    Human cell lines replicate and proliferate without ORC1 or ORC2, two subunits of the replication initiator protein complex ORC, which has till now been considered essential for DNA replication.