617 results found
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic, Yoon-Mi Hur ... Karri Silventoinen
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Risk factors affecting polygenic score performance across diverse cohorts

    Daniel Hui, Scott Dudek ... Marylyn D Ritchie
    Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
    1. Developmental Biology

    ESCRT-III-dependent adhesive and mechanical changes are triggered by a mechanism detecting alteration of septate junction integrity in Drosophila epithelial cells

    Thomas Esmangart de Bournonville, Mariusz K Jaglarz ... Roland Le Borgne
    In response to disruption of barrier functions mediated by septate junctions, Drosophila epithelial cells restrict endosomal degradation of transmembrane cell adhesion proteins to promote their recycling in order to maintain tissue integrity.
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana, Gabriella Mosca ... Célia Baroux
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.
    1. Ecology

    Tree species and genetic diversity increase productivity via functional diversity and trophic feedbacks

    Ting Tang, Naili Zhang ... Xiaojuan Liu
    Species and genetic diversity promote tree community productivity by increasing functional diversity and reducing herbivore damage and soil fungal diversity.
    1. Neuroscience

    Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

    Youna Vandaele, Nagaraj R Mahajan ... Patricia H Janak
    Dorsomedial and dorsolateral striatal neural activity differ during early learning of action sequences but do not change with performance improvement across sessions, and become similar after extended training.
    1. Physics of Living Systems

    Control of nuclear size by osmotic forces in Schizosaccharomyces pombe

    Joël Lemière, Paula Real-Calderon ... Fred Chang
    The volume of the nucleus is dictated by a balance of colloid osmotic forces from the nucleoplasm and cytoplasm.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Neuroscience

    Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice

    Michael A Gaffield, Britton A Sauerbrei, Jason M Christie
    The activity of cerebellar Purkinje cells both represents and participates in organizing the temporal structure of a periodically performed motor action.
    1. Neuroscience

    Whole-body connectome of a segmented annelid larva

    Csaba Verasztó, Sanja Jasek ... Gáspár Jékely
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling

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