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    1. Neuroscience

    Critical role for Piccolo in synaptic vesicle retrieval

    Frauke Ackermann et al.
    The active zone protein Piccolo regulates efficient recycling of SVs via Pra1 and Rab5 and is therefore critical for integrity and reliability of synaptic function.
    1. Neuroscience

    Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

    Minh Q Nguyen et al.
    Peripheral injury induces a programmed but reversible transformation of gene expression in somatosensory neurons providing a mechanism to regulate sensory input during wound healing.
    1. Biochemistry and Chemical Biology

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Matthew E Cockman et al.
    Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Transcriptome maps of general eukaryotic RNA degradation factors

    Salma Sohrabi-Jahromi et al.
    Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.
    1. Cell Biology

    The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

    Rolf M Schmidt et al.
    Endoplasmic reticulum stress in yeast activates not only the UPR but also Rpn4, promoting the clearance of misfolded proteins from the cytosol as part of a modular cross-compartment stress response.
    1. Cell Biology
    2. Neuroscience

    EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling

    Catrina M Loucks et al.
    C. elegans EFHC1 influences neuronal transmission through the cilium and the synapse.
    1. Neuroscience

    Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain

    Ken Sugino et al.
    A transcriptome dataset of nearly 200 genetically identified mouse neuronal cell types revealed that short low-noise homeobox transcription factors and long neuronal effector genes best distinguish neuronal cell types.
    1. Neuroscience

    Synapse-specific opioid modulation of thalamo-cortico-striatal circuits

    William T Birdsong et al.
    By differentially modulating the two major excitatory inputs to the striatum, mu- and delta-opioid receptors regulate the balance between thalamic and cortical inputs to the striatum.
    1. Immunology and Inflammation

    HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

    Rachael Laura Philips et al.
    CD4 lineage commitment requires HDAC3 to prevent premature upregulation of CD8 lineage genes during T cell development.