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    1. Cancer Biology

    STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

    Huan Fang, Huichun Liang ... Ceshi Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

    Fan Zhang, Yuan Wang ... Xianpeng Ge
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Terminal tracheal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

    Judith Bossen, Reshmi Raveendran ... Thomas Roeder
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Microbiology and Infectious Disease

    Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

    Lianhua Qin, Junfang Xu ... Haipeng Liu
    Galectin-9 directly binds to arabinogalactan (AG), leading to the identification of AG-specific monoclonal antibodies that effectively inhibit Mycobacterium tuberculosis growth, providing insights for novel tuberculosis therapies.
    1. Immunology and Inflammation

    Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

    Javier Ruiz-Navarro, Sara Fernández-Hermira ... Manuel Izquierdo Pastor
    FMNL1β is phosphorylated on S1086 in a protein kinase C δ (PKCδ)-dependent manner and S1086-phosphorylated FMNL1β acts downstream of PKCδ to regulate centrosome and multivesicular bodies polarization to the immunological synapse and exosome release.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    PRR adjuvants restrain high stability peptides presentation on APCs

    Bin Li, Jin Zhang ... Chao Wu
    Adjuvants, MPLA and CpG especially, modulate the peptide repertoires presented on the surface of APCs, preferring the presentation of low-affinity exogenous peptides rather than high-affinity peptides.
    1. Stem Cells and Regenerative Medicine

    Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

    Jacob W Klemm, Chloe Van Hazel, Robin E Harris
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Evolutionary Biology
    2. Immunology and Inflammation

    An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

    Shang Geng, Xing Lv ... Tianjun Xu
    5’ppp-RNA, a traditional ligand for RIG-I, can be recognized by MDA5 in species such as Miichthys miiuy and Gallus gallus that lack RIG-I.
    1. Immunology and Inflammation

    Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology
    2. Immunology and Inflammation

    S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

    Daniel M Williams, Andrew A Peden
    Recruitment of NLRP3 to the Golgi is controlled by the reversible addition of a lipid anchor adjacent to the polybasic region.
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