Browse the search results

A neuron-specific circular RNA keeps neuronal differentiation in check by lowering transcription rates from key neuronal marker genes.

Kif26b, a new component of the evolutionarily conserved Wnt5a-Ror signaling pathway, is controlled by regulated proteolysis and plays crucial roles in mediating vertebrate embryonic tissue morphogenesis.

Some NKX2-5 mutations that cause congenital heart disease retain transcriptional activity and can bind to many off-target genes, in part through their interactions with cofactors.

The SH3 domain of BIN1 mediates an unexpectedly large array of interactions, which is perturbed by missense variants.

Combining phylogenetic and functional approaches, it is shown that the protein sequence, the proliferative activity, and a regulatory element of TRNP1 co-evolve with brain size and folding.

Calsyntenin-3 functions in cerebellar Purkinje neurons as a postsynaptic adhesion molecule that, unexpectedly, suppresses excitatory parallel-fiber synapse numbers but boosts inhibitory synapse numbers and thereby controls the excitatory/inhibitory balance of Purkinje neurons.

Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.

A pathogen effector mimics starvation-induced autophagy by subverting host endomembrane trafficking to stimulate biogenesis of autophagosomes around pathogen feeding sites, revealing how pathogens interlock distinct host compartments to facilitate infection.

PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.