Glenn A Maston, Lihua Julie Zhu ... Michael R Green
The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.
A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
Anca M Farcas, Neil P Blackledge ... Robert J Klose
A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
The nematode worm C. elegans consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.
Xiao-chen Bai, Israel S Fernandez ... Sjors HW Scheres
A combination of direct-electron detectors and statistical movie processing allows ribosome cryo-EM structures to be determined to resolutions that were previously only attainable by X-ray crystallography.
Research on humans and dogs reveals that the communities of microorganisms found on the skin, on the tongue and in the intestine are affected differently by age and cohabitation.