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Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons
Jason D Vevea, Edwin R Chapman
Knockoff is a tool for researchers who wish to acutely disrupt a membrane protein.
Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling
Pietro Fazzari et al.
Genetic rescue experiments reveal that γ-secretase enzymes containing Aph1b subunits control signalling by type III neuregulin 1, with implications for schizophrenia.
Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
Julie Bruyère et al.
Reducing Akt-mediated huntingtin phosphorylation decreases APP accumulation at the synapse by reducing its anterograde axonal transport and ameliorates learning and memory in a mouse model of familial Alzheimer disease.
sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors
Justin J Grassmeyer et al.
The vesicular Ca
sensor synaptotagmin-1 regulates both fast phasic and slow tonic glutamate release at ribbon synapses of rod and cone photoreceptor cells.
Immunology and Inflammation
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody
Karina Kaczmarek-Hajek et al.
A novel BAC transgenic mouse model reveals glial restriction of P2X7 expression in the central and peripheral nervous systems.
Biochemistry and Chemical Biology
Computational and Systems Biology
Coevolution-based inference of amino acid interactions underlying protein function
Victor H Salinas, Rama Ranganathan
A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest
Joseph G Duman et al.
The adhesion-GPCR BAI1 shapes dendritic arbors in the hippocampus by associating with Bcr late in development and stimulating its RhoA-GEF activity, resulting in dendritic growth arrest.
Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects
Romana Tomasoni et al.
Excessive inflammation of the brain in early life predisposes individuals to neurodevelopmental disorders by preventing synapses from developing correctly.
Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain
Akiko Terauchi et al.
Feedback signaling between the synapse and nucleus via FGF22 and IGF2 directs the activity-dependent stabilization of presynaptic terminals in the mouse hippocampus.
Dendritic mitochondria reach stable positions during circuit development
Michelle C Faits et al.
Mitochondria reach stable positions in dendrites during a critical developmental period of high motility.
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