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    1. Structural Biology and Molecular Biophysics

    Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

    Rahul Chadda, Nathan Bernhardt ... Janice L Robertson
    Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

    Robert LeDesma, Brigitte Heller ... Alexander Ploss
    A combined computational, genetic, and biochemical analysis of the hepatitis E virus open reading frame 1 (ORF1) protein identifies a novel domain-domain interaction that is vital for fitness and supports a proposed structural model of the ORF1 polyprotein.
    1. Computational and Systems Biology
    2. Ecology

    Combining agent-based, trait-based and demographic approaches to model coral-community dynamics

    Bruno Sylvain Carturan, Jason Pither ... Lael Parrott
    A new agent-based model enables predicting how coral species richness and functional diversity affect the functioning and resilience of coral reef ecosystems.
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.
    1. Neuroscience

    Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

    Mahmood S Hoseini, Bryan Higashikubo ... Jeanne T Paz
    Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Oomycete small RNAs bind to the plant RNA-induced silencing complex for virulence

    Florian Dunker, Adriana Trutzenberg ... Arne Weiberg
    Small RNAs of distantly related plant pathogens, such as fungi and oomycetes, hijack the plant RNA-induced silencing complex to favor host infection.
    1. Neuroscience

    A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

    Lea Ankri, Zoé Husson ... Marylka Yoe Uusisaari
    The glycinergic neurons of the cerebellar nuclei project extensively to the cerebellar cortex and inhibit GABAergic Golgi cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

    David A Murphy, Eyal Elyashiv ... Guy Sella
    Background selection is shown to be the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes.
    1. Computational and Systems Biology

    Spatiotemporal establishment of dense bacterial colonies growing on hard agar

    Mya R Warren, Hui Sun ... Terence Hwa
    A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
    1. Developmental Biology

    Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination

    Ruonan Zhao, Emma L Moore ... Paul A Trainor
    Epithelial to mesenchymal transition (EMT) is a continuous process, in which the transition or intermediate states can be molecularly and spatially defined, shedding new light on development and disease EMT.