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The first-in-class, humanized, epitope-specific FSH-blocking antibody MS-Hu6 is efficacious, durable, and manufacturable, and is therefore poised for further development towards future testing in human trials for osteoporosis, obesity, dyslipidemia and neurodegeneration.

A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.

Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.

Genetic loss-of-function approaches and functional calcium imaging reveal cholecystokinin as the primary regulator of follicle-stimulating hormone in zebrafish, redefining our understanding of gonadotropin regulation in vertebrates.

When ancestral Xenopus returned to water ~170mya, they evolved a new method for producing courtship calls underwater without airflow, using vibrations that also preserve essential acoustic information on species identity.

The amyloid polymorph selection that occurs during α-synuclein aggregation is dictated by environmental conditions, in particular pH, with the largest variety of structures being observed near neutral pH.

The yeast enzyme CTP synthase assembles inactive filaments that are driven to polymerization through the drop in cytoplasmic pH accompanying starvation.

Plant roots can rapidly change the acidity of their cell walls and the root-soil interface to efficiently navigate in the soil environment.

Instead of repelling, Desmodium, a hallmark of pest suppressive sustainable intercropping, acts as a mechanical and developmental barrier to larvae, thereby truncating population development.

A combination of single-cell analysis, genomics, and simulations shows that a glutamine-rich low-complexity sequence in the SWI/SNF chromatin remodeling complex senses transient intracellular acidification as a signal for cells to switch their global transcriptional program.