1,375 results found
    1. Cell Biology
    2. Developmental Biology

    Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

    Katarzyna Nowak et al.
    Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations.
    1. Cancer Biology
    2. Cell Biology

    PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

    Arman Javadi et al.
    PTEN organizes multicellular architecture by non-catalytic scaffolding of spatially localized β-Arrestin1/ARHGAP21/Cdc42 protein complexes to control mitotic spindle orientation, multicellular configuration and lumen formation.
    1. Neuroscience

    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

    Estibaliz González-Fernández et al.
    OPC-specific genetic inhibition of Akt upstream and downstream molecules in the mouse, and simultaneous OPC fate analysis reveal that PTEN-AKT-GSK3b forms a persistent negative signaling pathway for OL development, in parallel with the AKT-mTORC1 pathway.
    1. Cell Biology
    2. Neuroscience

    The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

    Jana Dorfman Marcette et al.
    The minus-ends of microtubules have been implicated as part of a damage sensor to initiate remodeling of nerve cells.
    1. Cell Biology

    α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism

    Amin Khalifeh-Soltani et al.
    The milk protein Mfge8 promotes fat uptake and slows gastrointestinal motility to optimize nutrient absorption.
    1. Cancer Biology
    2. Cell Biology

    Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

    Onur Cizmecioglu et al.
    A unique two-step mechanism of plasma membrane recruitment and activation governs G-protein-coupled receptor mediated PI3K signaling.
    1. Developmental Biology

    Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

    Nils O Lindström et al.
    The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

    David Bolduc et al.
    C-terminal phosphorylation of the lipid phosphatase PTEN drives a reduction in membrane affinity and leads to a more compact conformation that involves a C2 domain-tail interaction.
    1. Cell Biology
    2. Developmental Biology

    The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium

    Joaquim Grego-Bessa et al.
    In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.

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