2,751 results found
  1. Developing kidneys: an interview with Peter Hohenstein

    Originally from the Netherlands, Peter Hohenstein has been in Edinburgh since 2001 and now has his own group in The Roslin Institute, studying the link between normal kidney development and kidney disease. He is married and has a 4 year old daughter (and three cats), and he enjoys music, ‘mainly old stuff with lots of guitars’.
  2. A notepad and pen next to a laptop

    Redesigning an online scientific journal from the article up II: User testing

    How we validated our ideas using HTML prototypes and real users.
    1. Developmental Biology

    Cytoplasmic sharing through apical membrane remodeling

    Nora G Peterson et al.
    Apical membrane remodeling in a resorptive Drosophila epithelium generates a shared multinuclear cytoplasm.
    1. Cell Biology
    2. Developmental Biology

    circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation

    Anne Kruse Hollensen et al.
    A neuron-specific circular RNA keeps neuronal differentiation in check by lowering transcription rates from key neuronal marker genes.
    1. Neuroscience

    Mesoscopic-scale functional networks in the primate amygdala

    Jeremiah K Morrow et al.
    Multivariate data decomposition applied to local field potentials recorded from the primate amygdala revealed simultaneously active and functionally distinct networks, defined by anatomical boundaries between the nuclei.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation

    CM Schooling et al.
    Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.
    1. Neuroscience

    Testicular hormones mediate robust sex differences in impulsive choice in rats

    Caesar M Hernandez et al.
    Sex differences in impulsive decision making, such that males are less impulsive than females, are critically dependent upon testicular but not ovarian hormones.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    In-host population dynamics of Mycobacterium tuberculosis complex during active disease

    Roger Vargas et al.
    Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

    Palur V Raghuvamsi et al.
    SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.
    1. Cancer Biology

    Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

    Connor Rogerson et al.
    Genome-wide redistribution of KLF5 binding leads to activation of a cell cycle gene expression programme and proliferation control in oesophageal cancer.

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