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DNA-PK and PTEN protect breast cancer cells from lethal replication stress induced by the WEE1 inhibitor AZD1775 and constitute new potential biomarkers for AZD1775 sensitivity.

OPC-specific genetic inhibition of Akt upstream and downstream molecules in the mouse, and simultaneous OPC fate analysis reveal that PTEN-AKT-GSK3b forms a persistent negative signaling pathway for OL development, in parallel with the AKT-mTORC1 pathway.

Conditioned olivocerebellar network activity elicits transient spike pauses and timed spike facilitation in the neurons of interposed nuclei that predicts and likely causes conditioned eyelid responses on a trial-by-trial basis.

The brain’s projection of linguistic knowledge onto speech is reflected by the automatic, reflexive neural tracking of phrases, while the distribution of phrasal-rate tracking and connectivity, particularly the involvement of inferior frontal cortex, is subject to task demands.

Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.

In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.

The milk protein Mfge8 promotes fat uptake and slows gastrointestinal motility to optimize nutrient absorption.

The minus-ends of microtubules have been implicated as part of a damage sensor to initiate remodeling of nerve cells.

The protein PTRN-1 anchors microtubules in neuronal branches to promote proper neuron morphology and function in Caenorhabditis elegans.

A unique two-step mechanism of plasma membrane recruitment and activation governs G-protein-coupled receptor mediated PI3K signaling.