1,769 results found
  1. Episode 42: eLife at five

    In this special episode, we hear about photosynthesis, forensics, peer review, and the past, present and future of eLife.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Edited by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
  2. October 2013

    Episode 5: October 2013

    In this episode we hear about how chimpanzees use conceptual metaphors, hyperactive sperm, the use of bacteria to estimate the time of death, stem cells and smoking, and a new type of bacteria.
  3. October 2014

    Episode 15: October 2014

    In this episode we hear about influenza pandemics, eating too much, cannabis and the brain, HIV cure research, and the evolution of sea squirts.
    1. Physics of Living Systems

    High-speed motility originates from cooperatively pushing and pulling flagella bundles in bilophotrichous bacteria

    Klaas Bente et al.
    Bacteria reach swimming speeds of several hundred body lengths per second and change direction in less than 5 ms by using coordinated flagella bundle agitation.
    1. Chromosomes and Gene Expression

    PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

    Shuchi Agrawal Singh et al.
    A key transcription-factor for osteogenic differentiation, PLZF, acts as a transcriptional activator by binding to active developmental enhancers and facilitates mediator recruitment, but is not involved in enhancer looping.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

    Murilo Delgobo et al.
    Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

    Andrea Brenna et al.
    Cyclin-dependent kinase 5 regulates the circadian clock involving phosphorylation of the PER2 protein.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.
    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash et al.
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.

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