24 results found
    1. Cancer Biology

    Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

    Matthew F Pech et al.
    CRISPR/Cas9 screens reveal a role for the ubiquitin ligase substrate adaptor DCAF15 in the immune surveillance of cancer cells by natural killer cells.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Biochemistry and Chemical Biology

    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

    Sungki Hong et al.
    LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Functional proteomic atlas of HIV infection in primary human CD4+ T cells

    Adi Naamati et al.
    Identification and characterisation of proteins and processes regulated by HIV in primary human CD4+ T cells using an HIV reporter virus for one-step, antibody-free magnetic selection.
    1. Cell Biology
    2. Immunology and Inflammation

    Small molecule inhibition of Csk alters affinity recognition by T cells

    Boryana N Manz et al.
    The T cell response, especially to weak agonists, is enhanced by acute Csk inhibition.
    1. Immunology and Inflammation

    High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

    Antoine Marçais et al.
    Chronic engagement of Natural killer cell inhibitory receptors by MHC-I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.
    1. Neuroscience

    Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body

    Michael-John Dolan et al.
    The generation and systematic characterisation of driver lines labelling a large number of neurons in the Drosophila innate olfactory processing centre bridges electron microscopy neuronal reconstructions, circuits and behaviour.
    1. Computational and Systems Biology
    2. Neuroscience

    Blood transcriptome based biomarkers for human circadian phase

    Emma E Laing et al.
    An unbiased modelling approach shows that only a few blood transcriptome samples are required to accurately assess the human circadian melatonin phase, even during altered sleep schedules.
    1. Cell Biology

    Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

    Roberto Villaseñor et al.
    Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.
    1. Cell Biology
    2. Neuroscience

    Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

    Santiago Vernia et al.
    Metabolic stress-induced activation of the JNK3 protein regulates excitatory transmission onto AgRP neurons to regulate food consumption.

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