46 results found
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

    Chase A Weidmann et al.
    Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO hyperactivity drives premature aging of Norad-deficient mice

    Florian Kopp et al.
    Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Noncoding RNA: Aging well with Norad

    Filipa Carvalhal Marques, Igor Ulitsky
    In mice, deleting a long noncoding RNA drives premature aging.
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    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

    Vandita D Bhat et al.
    Motif length plays a critical role in the specification of biological function within a conserved family of RNA-binding proteins.
    1. Developmental Biology

    Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition

    Masatoshi Hara et al.
    The threonine kinase controls maternal mRNA translation phosphorylate components of the translational machinery, including translational repressors, which appear to inactivate to promote the oocyte-to-embryo transition.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Plant-virus Interactions: Caught in a TrAP

    Delfina A Ré, Pablo A Manavella
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    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Genetics and Genomics
    2. Plant Biology

    Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite

    Mark McMullan et al.
    Hybridization and introgression blur species boundaries and broaden genetic diversity available for adaptation; and widespread introgression underpins the evolution of races of the generalist pathogen Albugo candida that specialise on different host plant species.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Gene activation by a CRISPR-assisted trans enhancer

    Xinhui Xu et al.
    Both exogenous and endogenous genes can be highly activated in cells by a new dCas9-based activator, CRISPR-assisted trans enhancer, that can be used to activate genes for biomedical applications.
    1. Cell Biology
    2. Plant Biology

    Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogen

    Yasin F Dagdas et al.
    Defense-related selective autophagy mediated by the antimicrobial autophagy cargo receptor NBR1/Joka2 is diverted to pathogen penetration sites to restrict plant colonization by the oomycete pathogen Phytophthora infestans.

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