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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

    Hyun Bong Park et al.
    A new type of hybrid nonribosomal peptide synthetase (NRPS)-like-pteridine synthase biosynthetic pathway has been illuminated via genome mining.
    1. Cell Biology
    2. Neuroscience

    The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons

    Eun Chan Park, Christopher Rongo
    The subcellular localization of the prolyl hydroxylase oxygen sensor in C. elegans neurons is regulated by p38 MAP kinase signaling.
    1. Neuroscience

    Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision

    Silvia JH Park et al.
    Anatomical and physiological analyses identified an inhibitory interneuron that is an integral part of the rod bipolar cell pathway, the circuit for night vision, of the mammalian retina.
    1. Neuroscience

    Lip movements entrain the observers’ low-frequency brain oscillations to facilitate speech intelligibility

    Hyojin Park et al.
    Rhythms of lip movements entrain low-frequency brain oscillations and facilitate audiovisual speech processing.
    1. Biochemistry and Chemical Biology

    Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

    Kelsie M Rodriguez et al.
    A combined chemical genetics, proximity labeling, and ADP-ribose site mapping approach shows that PARP-7 mono-ADP-ribosylates immune-relevant proteins on cysteine amino acids.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node

    Chung Park, John H Kehrl
    Intravital imaging with HIV-1 viral-like particle in mouse model reveals a mechanism for HIV-1 uptake by subcapsular sinus macrophages that facilitates HIV-1 spreading tofollicular dendritic and B cells.
    1. Neuroscience

    An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

    Bo-yong Park et al.
    Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.
    1. Neuroscience

    Alcohol potentiates a pheromone signal in flies

    Annie Park et al.
    For Drosophila melanogaster, the scent of alcohol—normally associated with preferred egg-laying sites—potentiates a male pheromone signal, thereby increasing the aggressive competition between males for the reproductive resource.
    1. Cell Biology
    2. Developmental Biology

    BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development

    Jaeyoung Shin et al.
    Genetic and biochemical approaches identify a new component of the cellular signaling machinery driving migration of limb muscle precursor cells during mouse embryogenesis and reveal the underlying molecular mechanism.
    1. Structural Biology and Molecular Biophysics

    De novo design of a homo-trimeric amantadine-binding protein

    Jooyoung Park et al.
    The first successful de novo design of a homo-trimeric protein that binds a C3 symmetric small molecule larger than a metal ion is an advance for computational protein design.