452 results found
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet et al.
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Neuroscience

    Network structure of brain atrophy in de novo Parkinson's disease

    Yashar Zeighami et al.
    The pattern of atrophy in Parkinson's disease is consistent with the disease spreading via intrinsic brain networks.
    1. Medicine
    2. Neuroscience

    Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease

    Roxanne Lofredi et al.
    Bradykinesia in Parkinson's disease may be associated to a dopamine-dependent recruitment failure of subthalamic activity in short bursts of gamma synchrony.
    1. Cell Biology
    2. Neuroscience

    Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

    Francois Singh et al.
    The most common Parkinson’s disease-associated mutation, LRRK2 G2019S, impairs mitophagy in clinically relevant cells within the mouse brain and this defect can be reversed using a novel LRRK2 inhibitor.
    1. Neuroscience

    Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease

    John P Grogan et al.
    Memory over 24 hours was impaired in Parkinson's patients off, rather than on, dopaminergic medication during reinforcement learning, whereas dopamine did not affect positive and negative reinforcement, in contrast to previous studies.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

    Atul Kumar et al.
    The structure of human PINK1 explains structural regulation and clarity on the impact of loss of function disease-associated mutations, which may stimulate future drug discovery efforts for both familial and idiopathic Parkinson's disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

    Chi G Weindel et al.
    Long studied in the context of the central nervous system, LRRK2 also functions in peripheral immunity by maintaining mitochondrial homeostasis in macrophages to regulate the type I interferon response.
    1. Medicine
    2. Neuroscience

    What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

    Dan Valsky et al.
    Aberrant striatal signaling does not induce drastic changes in the spontaneous discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Martin Steger et al.
    Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.
    1. Cell Biology

    A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

    Herschel S Dhekne et al.
    Pathogenic LRRK2kinase requires Rab10 and RILPL1 to block primary cilia formation, shortening cilia on cholinergic neurons needed for a hedgehog driven circuit that supports dopaminergic neurons in mouse brain.

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