7 results found
    1. Developmental Biology
    2. Neuroscience

    Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II

    Chwee Tat Koe, Ye Sing Tan ... Hongyan Wang
    Vibrator and PI4KIIIα that stimulate the synthesis of PI(4)P anchor non-muscle myosin II RLC (Sqh) to the plasma membrane and conversely Sqh associates with PI(4)P and facilitates its membrane localization during asymmetric division of neuroblasts.
    1. Cell Biology

    CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

    Kian-Yong Lee, Rebecca A Green ... Karen Oegema
    The CYK-4 subunit of the broadly conserved intercellular bridge component centralspindlin, but not its ZEN-4 subunit, is essential for the cytokinesis-like closure of intercellular bridges that cellularizes oocytes to separate them from germline syncytia.
    1. Cell Biology

    The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

    Donglei Zhang, Michael Glotzer
    Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.
    1. Cell Biology

    Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis

    Vikash Verma, Thomas J Maresca
    MT plus-end-mediated recruitment of a cortical pool of ECT2 trigger RhoA activation upon contact, which results in localized contractility during cytokinesis.
    1. Developmental Biology

    Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testis

    Kevin L Lu, Yukiko M Yamashita
    Genetic and cell biological study indicates that germ cells' connectivity serves as a mechanism to increase the sensitivity of germline to DNA damage, protecting the genome of gametes, in the Drosophila testis.
    1. Epidemiology and Global Health

    Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trial

    Nikkil Sudharsanan, Caterina Favaretti ... Alain Vandormael
    Small changes to the way COVID-19 vaccine side-effect rates are framed and communicated have meaningful impacts on individuals' vaccination intentions.
    1. Cell Biology
    2. Neuroscience

    Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding

    Rosalind Norkett, Urko del Castillo ... Vladimir I Gelfand
    Microtubule-microtubule sliding and neurite outgrowth in Drosophila is controlled by a Ser/Thr kinase Tricornered via phosphorylation of a 'mitotic' motor protein Pavarotti.

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