267 results found
    1. Chromosomes and Gene Expression
    2. Medicine

    Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

    Karthik Amudhala Hemanthakumar et al.
    Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.
    1. Biochemistry and Chemical Biology

    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

    Vidyasiri Vemulapalli et al.
    Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.
    1. Computational and Systems Biology
    2. Developmental Biology

    Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

    Nicholas J Everetts et al.
    A single-cell atlas of the developing Drosophila wing disc at two time points enables a detailed understanding of the signals exchanged between different cell populations during development.
    1. Medicine

    Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice

    Qi Sun et al.
    Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.
    1. Cell Biology
    2. Immunology and Inflammation

    Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

    Florence WJ Chioh et al.
    COVID-19 survivors, who are at risk for vascular complications, would benefit from close monitoring and preventive therapy.
    1. Neuroscience

    Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

    Yanan Chen et al.
    Oligodendrocytes with an enhanced ability to withstand cytotoxic stress display an increased capacity to remyelinate demyelination lesions of the CNS in the presence of an inflammatory environment.
    1. Genetics and Genomics
    2. Neuroscience

    Sequential perturbations to mouse corticogenesis following in utero maternal immune activation

    Cesar P Canales et al.
    Mid-gestational exposure to maternal immune activation drives a sequence of transcriptional signatures and developmental pathology in embryonic mouse cortex, culminating in altered lamination and cellular lineage specification.
    1. Cell Biology
    2. Developmental Biology

    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

    Xiaochen Fan et al.
    Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.
    1. Immunology and Inflammation

    Seroconversion stages COVID19 into distinct pathophysiological states

    Matthew D Galbraith et al.
    Stratification of COVID19 patients using quantitative metrics of seroconversion reveals distinct pathophysiological stages after SARS-CoV-2 infection, including key differences in immune cell types, inflammatory makers, and markers of organ function.
    1. Cell Biology
    2. Neuroscience

    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Kae-Jiun Chang et al.
    Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.

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