104 results found
    1. Microbiology and Infectious Disease

    ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

    Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

    Rupinder Singh Jandu, Mohammed Al-Seragi ... Franck Duong van Hoa
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

    Giuseppe Deganutti, Ludovico Pipitò ... Christopher A Reynolds
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice

    Lotfi Ferhat, Rabia Soussi ... Michel Khrestchatisky
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

    Laura Childers, Esther Park ... Michel Bagnat
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

    Ka Kiu Lee, Urszula Łapińska ... Stefano Pagliara
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Neuroscience

    Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

    Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

    Carlo Giannangelo, Matthew P Challis ... Darren J Creek
    M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.
    1. Cell Biology

    The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

    Liam C Hunt, Kudzai Nyamkondiwa ... Fabio Demontis
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Toxin-based screening of C-terminal tags in Escherichia coli reveals the exceptional potency of ssrA-like degrons

    Patrick C. Beardslee, Karl R. Schmitz
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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