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    1. Cancer Biology

    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

    Sawan Kumar Jha, Khushbu Rauniyar ... Michael Jeltsch
    Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber, Thomas Roder ... Matthias Erb
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer, Tyler M Earnest ... Zaida Luthey-Schulten
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamics

    Rupinder Singh Jandu, Mohammed Al-Seragi ... Franck Duong van Hoa
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

    Jason E Stajich, Brian Lovett ... Carolyn Elya
    Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
    1. Cell Biology

    Lipid hydroperoxides promote sarcopenia through carbonyl stress

    Hiroaki Eshima, Justin L Shahtout ... Katsuhiko Funai
    Genetic or pharmacological suppression of lipid peroxidation pathway protects skeletal muscle from disuse-induced atrophy and weakness in young and old mice.
    1. Microbiology and Infectious Disease

    Growth: Inside help from the microbiome

    Sneha Agrawal, Nichole A Broderick
    Elucidating the role of one of the proteins produced by Lactiplantibacillus plantarum reveals a new molecule that allows this gut bacterium to support the development of fruit fly larvae.
    Version of Record
    Insight
    1. Developmental Biology
    2. Plant Biology

    ECS1 and ECS2 suppress polyspermy and the formation of haploid plants by promoting double fertilization

    Yanbo Mao, Thomas Nakel ... Rita Groß-Hardt
    The endopeptidases ECS1 and ECS2 regulate double fertilization and their modulation is a powerful tool for the induction of haploids and the formation of triparental plants, which are two agronomically relevant breeding targets.
    1. Developmental Biology

    Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway

    Hyae Yon Kweon, Mi-Ni Lee ... Gholson J Lyon
    Mice doubly deficient for Naa10 and Naa12 display embryonic lethality, with both enzymes compensating for each other with amino-terminal acetylation of proteins in mouse development.
    1. Immunology and Inflammation

    B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism

    Eric E Irons, Melissa M Lee-Sundlov ... Joseph TY Lau
    B cells regulate production of neutrophils by a novel mechanism by releasing ST6Gal-1, an active sialyltransferase, that suppresses granulopoiesis.